Chemical Details
Nedaplatin
CAS No.: 95734-82-0
HS Code: 28439090
Molecular FormulaC2H8N2O3Pt
Molecular WEIGHT303.18 g/mol
IUPAC Nameazanide;2-hydroxyacetic acid;platinum(2+)
InChIKeyKLNFSAOEKUDMFA-UHFFFAOYSA-N
Nedaplatin is a second-generation cisplatin analogue with antineoplastic activity. Containing a novel ring structure in which glycolate is bound to the platinum by a bidentate ligand, nedaplatin forms reactive platinum complexes that bind to nucelophillic groups in DNA, resulting in intrastrand and interstrand DNA cross-links, apoptosis and cell death. This agent appears to be less nephrotoxic and neurotoxic compared to both cisplatin and carboplatin.
